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人S100鈣結合蛋白鈣粒蛋白A Elisa試劑盒
物品單位 價格 品牌
3200 Solarbio
  • 產地:北京
  • 貨號:SEKH-0421
  • 發布日期: 2020-08-10
  • 更新日期: 2020-08-10
產品詳細說明
產地 北京
保存條件 -20
品牌 Solarbio
貨號 SEKH-0421
檢測方法 雙抗體夾心法
CAS編號
保質期
規格
適應物種 Human
檢測限 31.2 - 2000 pg/mL
數量 999
用途范圍 Human
標記物
純度 %
樣本 血清/血漿/細胞培養上清
應用 Elisa試劑盒
是否進口
S100A8 (also MRP8 and calgranulin A) is a 10 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Human S100A8 is 93 amino acids (aa) in length. It contains two EF-hand motifs (aa 12 - 47 and 46 - 81) and one high-affinity Ca2+-binding site (aa 59 - 70). There may be one splice form that shows a 15 aa substitution for the C-terminal 14 amino acids. Although mouse S100A8 is cleaved by MMP-2 after Asn21, it is unclear if human S100A8 is susceptible. Full-length human S100A8 is 57% and 74% aa identical to mouse and canine S100A8, respectively.
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