產品目錄
大鼠晚期糖基化終末產物受體 Elisa試劑盒
物品單位 價格 品牌
2600 Solarbio
  • 產地:北京
  • 貨號:SEKR-0077
  • 發布日期: 2020-08-10
  • 更新日期: 2020-08-10
產品詳細說明
產地 北京
保存條件 -20
品牌 Solarbio
貨號 SEKR-0077
檢測方法 雙抗體夾心法
CAS編號
保質期
規格
適應物種 Rat
檢測限 31.2 - 2,000 pg/mL
數量 999
用途范圍 Rat
標記物
純度 %
樣本 血清/血漿/細胞培養上清
應用 Elisa試劑盒
是否進口
RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.
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