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人t-纖溶酶原激活物 Elisa試劑盒
物品單位 價格 品牌
3200 Solarbio
  • 產地:北京
  • 貨號:SEKH-0505
  • 發布日期: 2020-08-10
  • 更新日期: 2020-08-10
產品詳細說明
產地 北京
保存條件 -20
品牌 Solarbio
貨號 SEKH-0505
檢測方法 雙抗體夾心法
CAS編號
保質期
規格
適應物種 Human
檢測限 78.1-5000 pg/ml
數量 999
用途范圍 Human
標記物
純度 %
樣本 血清/血漿/細胞培養上清
應用 Elisa試劑盒
是否進口
Tissue Plasminogen Activator (tPA), also known as PLAT, is a 64-69 kDa extracellular glycoprotein that belongs to the peptidase S1 family of serine proteases. The biological effects of tPA include blood clot degradation, vascular remodeling, synaptic plasticity, and neurodegeneration in the brain following trauma. Human tPA is secreted as a 530 amino acid (aa) single chain polypeptide (36-562 aa) that contains an amino-terminal fibrin-"finger"-like domain, an epidermal growth factor-like domain, two kringle domains and a C-terminal serine protease catalytic domain (1, 2). The partially active single chain tPA is cleaved between Arg310-Ile311 by Plasmin, Kallikrein/KLKB1, and Coagulation Factor X/Xa to generate the mature two-chain disulfide-linked polypeptide. This mature form of tPA is 10-fold more catalytically active than the single chain (3, 4). From aa 36-562, human tPA shares 81% and 72% identity with mouse and rat tPA, respectively.
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