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K009372PAnti-SARS spike glycoprotein S1 Polyclonal Antibody
物品單位 價格 品牌
960 solarbio
  • 產地:北京
  • 貨號:K009372P
  • 發布日期: 2020-03-04
  • 更新日期: 2020-03-05
產品詳細說明
CAS編號
抗體名 Anti-SARS spike glycoprotein S1 Polyclonal Antibody
是否單克隆
靶點 SARS spike glycoprotein S1
用途范圍 WB 1:500-1000. IHC-P 1:100-500. IHC-F 1:100-500. ICC 1:100-500. IF 1:100-500
形態 液體
宿主 Rabbit
標記物
純度 %
免疫原 KLH conjugated synthetic peptide derived from SARS spike glycoprotein:101-200/1255
產地 北京
品牌 solarbio
貨號 K009372P
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
應用范圍 WB IHC-P IHC-F ICC IF
抗原來源
保質期
規格 50ul
產品用途 蛋白研究,分析,檢測
克隆性
適應物種 SARS-CoV
亞型 IgG
標識物
濃度 %
是否進口
背景資料:S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
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