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K009371PAnti-Phospho-Stat3-S727 Polyclonal Antibody
物品單位 價格 品牌
960 solarbio
  • 產地:北京
  • 貨號:K009371P
  • 發布日期: 2020-03-04
  • 更新日期: 2020-03-05
產品詳細說明
CAS編號
抗體名 Anti-Phospho-Stat3-S727 Polyclonal Antibody
是否單克隆
靶點 Phospho-Stat3-S727
用途范圍 WB 1:500-2000. IHC 1:50-200. IP 1:50-100.
形態 液體
宿主 Rabbit
標記物
純度 %
免疫原 A synthetic phosphorylated peptide around S727 of human Stat3
產地 北京
品牌 solarbio
貨號 K009371P
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
應用范圍 WB IHC IP
抗原來源
保質期
規格 50ul
產品用途 蛋白研究,分析,檢測
克隆性
適應物種 Human Mouse Rat
亞型 IgG
標識物
濃度 %
是否進口
背景資料:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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